The effects of biologically active substances in medicinal plants on the metabolic activity of neutrophils

0435426 - BFÚ 2015 RIV NL eng J - Journal Article
Lojek, Antonín - Denev, P. - Číž, Milan - Vašíček, Ondřej - Kratchanova, M.
The effects of biologically active substances in medicinal plants on the metabolic activity of neutrophils.
Phytochemistry Reviews. Roč. 13, č. 2 (2014), s. 499-510. ISSN 1568-7767. E-ISSN 1572-980X
R&D Projects: GA MŠMT(CZ) EE2.3.30.0030
Institutional support: RVO:68081707
Keywords : Phagocytes * Polyphenols * Polysaccharides
Subject RIV: BO - Biophysics
Impact factor: 2.407, year: 2014

Neutrophils are the typical effector cells of the innate immune response because they are the first leukocytes to be recruited to an inflammatory site where they engulf invading microorganisms and destroy them by multiple oxidative and non-oxidative mechanisms. The destructive potential of neutrophils requires the tight control of their recruitment into tissue compartments and the production of inflammatory mediators such as reactive oxygen species. These oxidants can be highly toxic not only for infectious agents but also for neighbouring host tissues resulting in various autoimmune and inflammatory diseases. Thus, a significant attention in medicine is paid to approaches designed to modulate the metabolic activity of neutrophils. Synthetic steroid and non-steroid compounds with adverse side effects are commonly used for this purpose. The effects of natural substances which can modulate the metabolic activity of neutrophils and which simultaneously would not exert any significant unfavourable side effects have recently been investigated.
Permanent Link: http://hdl.handle.net/11104/0239303