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Synthesis and biological properties of polysubstituted 5-nitrosopyrimidines
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SYSNO ASEP 0429005 Document Type C - Proceedings Paper (int. conf.) R&D Document Type The record was not marked in the RIV Title Synthesis and biological properties of polysubstituted 5-nitrosopyrimidines Author(s) Janeba, Zlatko (UOCHB-X) RID, ORCID
Čechová, Lucie (UOCHB-X) RID, ORCID
Žurek, Jiří (UOCHB-X)
Procházková, Eliška (UOCHB-X) RID, ORCID
Dračínský, Martin (UOCHB-X) RID, ORCIDNumber of authors 5 Source Title Chemistry of Nucleic Acid Components. 16th Symposium. - Praha : Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2014 / Hocek M. - ISBN 978-80-86241-50-0 Pages s. 285-286 Number of pages 2 s. Publication form Print - P Action Symposium on Chemistry of Nucleic Acid Components /16./ Event date 08.06.2014-13.06.2014 VEvent location Český Krumlov Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords polysubstituted 5-nitrosopyrimidines ; intramolecular hydrogen bond ; NMR spectroscopy Subject RIV CC - Organic Chemistry R&D Projects VG20102015046 GA MV - Ministry of Interior (MV) Institutional support UOCHB-X - RVO:61388963 Annotation 2,4,6-Triamino-5-nitrosopyrimidines have been reported to contain a strong intramolecular hydrogen bond between the 5-nitroso and 4- or 6-amino groups, thus forming an additional pseudoring. Such analogues were speculated to be good mimics of fused bicyclic derivatives, e.g. purines. A series of novel polysubstituted 2-amino-5-nitrosopyrimidines, as potential structural mimics of modifi ed purine nucleos(t)ides well-known for their important biological properties, has been designed and synthesized. The physicochemical and biological properties of the prepared polysubstituted 2-amino-5-nitrosopyrimidines are being evaluated. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2015
Number of the records: 1