Interleaved DCE and DSC-MRI

0422167 - ÚPT 2014 RIV SK eng C - Conference Paper (international conference)
Macíček, Ondřej - Jiřík, Radovan - Bartoš, M. - Šprláková, A. - Keřkovský, M. - Taxt, T. - Bartušek, Karel - Starčuk jr., Zenon
Interleaved DCE and DSC-MRI.
Zborník konferencie Trendy v biomedicínskom inženierstve. Košice: Technická univerzita v Košiciach, 2013, s. 177-180. ISBN 978-80-8086-204-6.
[Trendy v biomedicínskom inženierstve. Podbanské (SK), 03.07.2013-05.07.2013]
R&D Projects: GA ČR GAP102/12/2380; GA ČR GAP102/12/1104; GA MŠMT ED0017/01/01
Institutional support: RVO:68081731
Keywords : dynamic contrast enhanced * dynamic susceptibility contrast * perfusion * tumour * glioblastoma * human * brain
Subject RIV: BH - Optics, Masers, Lasers

Perfusion MRI is a popular diagnostics method for oncological diseases. There are two methods based on: T1 (DCE) or T2 (DSC) weighted acquisition. Basic DCE methods do not provide all intravascular perfusion parameters, but model mostly the contrast-agent extravasation. On the other hand, classical DSC methods provide only intravascular parameters valid in case of no extravasation. This contribution aims at combination of DSC and DCE-MRI to use their complimentary advantages in a new interleaved DCE-DSC-DCE acquisition and data processing. The use of the advanced aaTH model with Parkers AIF allows estimation of intravascular parameters also by the DCE method. In case of DSC, the effect of the contrast agent extravasation present in tumours is reduced by application of two contrast-agent boluses. Knowing the bolus peak times and doses, the contrast and post-contrast DCE sequences are connected and approximated by the aaTH model. This allows comparison of the intravascular parameters obtained with both methods and in future, simultaneous estimation of one perfusion-parameter set from the DCE and DSC sequences, leading to a more robust approach. Our method was evaluated on patient data with brain glioblastoma. The resulting perfusion parameters agreed with literature. The DSC and DCE perfusionparameter maps were in a good agreement, except for an unknown DSC vessels-size dependent scaling factor.
Permanent Link: http://hdl.handle.net/11104/0228366