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Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats

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    0392092 - FGÚ 2014 RIV US eng J - Journal Article
    Pravenec, Michal - Kožich, V. - Krijt, J. - Sokolová, J. - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Šilhavý, Jan - Oliyarnyk, O. - Kazdová, L. - Kurtz, T. W.
    Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats.
    American Journal of Hypertension. Roč. 26, č. 1 (2013), s. 135-140. ISSN 0895-7061. E-ISSN 1941-7225
    R&D Projects: GA MZd(CZ) NS10036; GA MŠMT(CZ) ME10019; GA ČR(CZ) GAP303/10/0505; GA MŠMT(CZ) 7E10067
    Institutional support: RVO:67985823
    Keywords : blood pressure * ectopic fat accumulation * folate deficiency * homocysteine * hypertension * oxidative stress * spontaneously hypertensive rat
    Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
    Impact factor: 3.402, year: 2013

    The SHR model is susceptible to the adverse metabolic and hemodynamic effects of low dietary intake of folate. The results are consistent with the hypothesis that folate deficiency can promote oxidative stress and multiple features of the metabolic syndrome that are associated with increased risk for diabetes and cardiovascular disease
    Permanent Link: http://hdl.handle.net/11104/0221064

     
     
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