Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast

0378822 - MBÚ 2013 RIV US eng J - Journal Article
Rinnerthaler, M. - Büttner, S. - Laun, P. - Heeren, G. - Felder, T. K. - Klinger, H. - Weinberger, M. - Stolze, K. - Groušl, Tomáš - Hašek, Jiří - Benada, Oldřich - Frýdlová, Ivana - Klocker, A. - Simon-Nobbe, B. - Jansko, B. - Breitenbach-Koller, B. - Eisenberg, T. - Gourlay, C. W. - Madeo, F. - Burhans, W. C. - Breitenbach, M.
Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 109, č. 22 (2012), s. 8658-8663. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA ČR GA204/09/1924; GA MŠMT MEB060902; GA MŠMT 7AMB12AT002; GA MŠMT LC545
Institutional research plan: CEZ:AV0Z50200510
Keywords : cell cycle * integral membrane reductase * wiskostatin
Subject RIV: EE - Microbiology, Virology
Impact factor: 9.737, year: 2012

The large protein superfamily of NADPH oxidases (NOX enzymes) is found in members of all eukaryotic kingdoms: animals, plants, fungi, and protists. The physiological functions of these NOX enzymes range from defense to specialized oxidative biosynthesis and to signaling. In filamentous fungi, NOX enzymes are involved in signaling cell differentiation, in particular in the formation of fruiting bodies. On the basis of bioinformatics analysis, until now it was believed that the genomes of unicellular fungi like Saccharomyces cerevisiae and Schizosaccharomyces pombe do not harbor genes coding for NOX enzymes. Nevertheless, the genome of S. cerevisiae contains nine ORFs showing sequence similarity to the catalytic subunits of mammalian NOX enzymes, only some of which have been functionally assigned as ferric reductases involved in iron ion transport
Permanent Link: http://hdl.handle.net/11104/0210181