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Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension
- 1.0377329 - FGÚ 2013 RIV GB eng J - Journal Article
Neckář, Jan - Kopkan, L. - Husková, Z. - Kolář, František - Papoušek, František - Kramer, H. J. - Hwang, S.H. - Hammock, B.D. - Imig, J. D. - Malý, J. - Netuka, I. - Ošťádal, Bohuslav - Červenka, L.
Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
Clinical science. Roč. 122, č. 11 (2012), s. 513-525. ISSN 0143-5221. E-ISSN 1470-8736
R&D Projects: GA AV ČR(CZ) IAAX01110901; GA AV ČR(CZ) KAN200520703; GA MŠMT(CZ) 1M0510
Institutional research plan: CEZ:AV0Z50110509
Keywords : hypertension * angiotensin II * kidney * epoxyeicosatrienoic acids * soluble epoxide hydrolase inhibitor * myocardial ischemia/reperfusion injury
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 4.859, year: 2012
The present study was undertaken to evaluate the effects of chronic treatment with c-AUCB, a novel inhibitor of soluble epoxide hydrolase (sEH) which is responsible for the conversion of biologically active epoxyeicosatrienoic acids to biologically inactive dihydroxyeicosatrienoic acids, on blood pressure and myocardial infarct size in male heterozygous Ren-2 transgenic rats with established hypertension. Our findings indicate that chronic inhibition of sEH exhibits antihypertensive and cardioprotective actions in this transgenic model of angiotensin II-dependent hypertension
Permanent Link: http://hdl.handle.net/11104/0209513
Number of the records: 1