Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus.domesticus and M. m. musculus

0374434 - ÚBO 2012 FR eng A - Abstract
Janoušek, V. - Wang, L. - Luzynski, K. - Dufková, Petra - Mrkvicová Vyskočilová, Martina - Nachman, M. W. - Munclinger, P. - Macholán, Miloš - Piálek, Jaroslav - Tucker, P. K.
Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus.domesticus and M. m. musculus.
ECM 2011. VIth EuropeanCongress of Mammalogy. Paris: Université P. et M. Curie, 2011 - (Denys, C.). s. 46
[European Congress of Mammalogy /7./. 19.07.2011-23.07.2011, Paris]
Institutional research plan: CEZ:AV0Z60930519; CEZ:AV0Z50450515
Keywords : house mouse * hybrid zone
Subject RIV: EG - Zoology
http://www.alphavisa.com/ecm2011/pdf/ECM2011-Abstract_Book.pdf

A hybrid zone where two house mouse subspecies (M. m. musculus and M. m. domesticus) meet occurs across central Europe. Several transects from different parts of the hybrid zone have been studied, revealing evidence that the hybrid zone is a tension zone resulting from dispersal of parental types and selection against hybrids. While these studies suggest a large role for the sex chromosomes, as well as multiple regions of autosomal chromosomes, they have not provided a sufficiently detailed analysis of the genetic architecture of reproductive isolation due to insufficient marker coverage on a genome-wide scale. The goal of our study is to detect and characterize genomic regions in house mice underlying reproductive isolation. We used 1401 markers evenly spaced across the genome to analyze the genetic interactions such as Dobzhansky-Muller incompatibilities across two transects. Using genotype data from 1301 mice collected from two different transects, we employed cline theory to assess genome-wide variation in patterns of introgression. Using genotype data from mice collected from two populations, one from each transect, we also used information on linkage disequilibrium to identify regions of the genome under putative selection. The results of these two analyses in combination with knowledge of biologically relevant gene content reveal regions of interest and our preliminary results suggest an important role of spermatogenesis genes in reproductive isolation between these taxa.
Permanent Link: http://hdl.handle.net/11104/0207356