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The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies
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SYSNO ASEP 0346788 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies Author(s) Živný, J. (CZ)
Klener, P. (CZ)
Pytlík, R. (CZ)
Anděra, Ladislav (UMG-J) RIDSource Title Current Pharmaceutical Design - ISSN 1381-6128
Roč. 16, č. 1 (2010), s. 11-33Number of pages 23 s. Language eng - English Country GB - United Kingdom Keywords apoptosis ; cancer therapy ; leukemia Subject RIV EB - Genetics ; Molecular Biology R&D Projects NS10287 GA MZd - Ministry of Health (MZ) 1M0506 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000272773200003 DOI 10.2174/138161210789941883 Annotation Apoptosis is a normal aspect of human physiology ensuring tissue homeostasis. Evasion of endogenous cell death processes, including apoptosis, represents one of the characteristics of cancer. Defects in the physiological mechanisms of apoptosis contribute to the pathological cell expansion and to the development and progression of cancer. Resistance of malignant cells to cancer therapeutic agents may be, in some cases, caused by dysregulation of apoptotic pathways, e.g. BCL2 or IAP overexpression. The understanding of the physiological mechanisms that control apoptosis and the elucidation of apoptotic defects in cancer cells may lead to the development of targeted cancer therapies. Apoptotic pathways, molecules involved in the cross-talk between individual apoptosis pathways and promising new anti-cancer agents, which trigger directly or indirectly apoptosis of hematologic cancer cells, are reviewed in this article. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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