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Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei
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SYSNO ASEP 0318331 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei Title Mitochondriální lokalizace ale ne procesování lidského frataxinu jsou esenciální pro záchranu frataxinové deficiente u Trypanosoma brucei Author(s) Long, Shaojun (BC-A)
Jirků, Milan (BC-A) RID
Ayala, F. J. (US)
Lukeš, Julius (BC-A) RID, ORCIDNumber of authors 4 Source Title Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424
Roč. 105, č. 36 (2008), s. 13468-13473Number of pages 6 s. Language eng - English Country US - United States Keywords frataxin ; mitochondrion ; Trypanosoma ; Kinetoplastida Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA500960705 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC07032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 2B06129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA204/06/1558 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000259251700053 DOI 10.1073/pnas.0806762105 Annotation Trypanosoma brucei is the most genetically tractable representative of the domain Excavata and also the causative agent of human sleeping sickness and ruminant nagana. We have attempted to rescue the T. brucei cells with down-regulated frataxin using the human frataxin, the defects of which result in Friedriech’s ataxia. Despite the evolutionary distance between humans and trypanosomes, human frataxin was not only efficiently imported into the T. brucei mitochondrion via its long genuine import signal, but also successfully rescued the phenotype. The rescue was, however, fully dependent on mitochondrial localization of human frataxin. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2009
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