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Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells
- 1.0173635 - UEM-P 20023085 RIV US eng J - Journal Article
Tvrdík, Daniel - Djaborkhel, Rashed - Nagy, Alexandr - Eckschlager, T. - Raška, Ivan - Müller, Julius
Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells.
Journal of Structural Biology. Roč. 140, - (2002), s. 49-56. ISSN 1047-8477. E-ISSN 1095-8657
R&D Projects: GA ČR GA304/01/0564
Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 111100003
Keywords : cyclin-dependent kinase * follicular lymphoma * retinoblastoma protein
Subject RIV: EA - Cell Biology
Impact factor: 4.194, year: 2002
The kinase activity of cdk2, cdk4, and cdk6 was significantly reduced and hypophosphorylation of pRb on serine 795 (S795) and threonine 373 (T373) was observed. Both cdk4 and cdk6 were notably dissociated from cyclin D co-factors, while cyclin E-cdk2 complexes remained coupled in TGFß1-treated cells. TGFß1-induced growth arrest was associated with notably increased binding of p21WAF1 to cdk4 and cdk6.
Permanent Link: http://hdl.handle.net/11104/0070664
Number of the records: 1