INTERACTION OF AROMATIC CYTOKININS WITH HUMAN LIVER MICROSOMAL CYTOCHROMES P450

0083394 - ÚEB 2008 RIV CZ eng J - Journal Article
Anzenbacherová, E. - Janalík, J. - Popa, Igor - Strnad, Miroslav - Anzenbacher, P.
INTERACTION OF AROMATIC CYTOKININS WITH HUMAN LIVER MICROSOMAL CYTOCHROMES P450.
[INTERACTION OF AROMATIC CYTOKININS WITH HUMAN LIVER MICROSOMAL CYTOCHROMES P450.]
Biomedical Papers. Roč. 149, č. 2 (2005), s. 349-351. ISSN 1213-8118. E-ISSN 1804-7521
Institutional research plan: CEZ:AV0Z50380511
Keywords : Cytokinins * Cyclin dependent kinase inhibitor * Cytochrome P450
Subject RIV: CE - Biochemistry
http://publib.upol.cz/~obd/fulltext/Biomed/2005/2/349.pdf

Aromatic cytokinins (ortho-topolin riboside, 6-benzylaminopurine riboside and 6-(2-hydroxy-3-methoxybenzyla mino)purine riboside) were tested for their possible interaction with human liver microsomal cytochromes P450 by absorption difference spectroscopy. All three compounds were shown to bind to the CYP enzymes producing a high to low spin shift of the heme iron yielding a Soret absorption band shift to approximately 425 nm. As this type of spectral change means that the substance is able to bind directly to the heme iron, the results obtained open the possibility of an interaction of these compounds with metabolism of other drugs or, in general, with other substrates of cytochromes P450.

INTERACTION OF AROMATIC CYTOKININS WITH HUMAN LIVER MICROSOMAL CYTOCHROMES P450.
Permanent Link: http://hdl.handle.net/11104/0146654