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Effects of oncogenic fusion proteins on chromatin PML-RAR - A model to cure leukemia
- 1.0080973 - BFÚ 2007 US eng A - Abstract
Pellicci, P. G. - Falk, Martin - Lukášová, Emilie - Kozubek, Stanislav
Effects of oncogenic fusion proteins on chromatin PML-RAR - A model to cure leukemia.
[Vliv onkogenních fúzních proteinů na chromatin - PML-RAR jako model pro léčbu leukémií.]
Abstract. La Jolla, 2007. s. 28-28.
[Symposium on Biological Complexity: Diseases of Transcription. 11.01.2007-14.01.2007, La Jolla]
R&D Projects: GA ČR(CZ) GP204/06/P349; GA MŠMT(CZ) 1P05OC084; GA MŠMT(CZ) LC535
Institutional research plan: CEZ:AV0Z50040507
Keywords : PML/RARa oncogene * acute promyelocytic leukemia * gene down-regulation
Subject RIV: BO - Biophysics
In this work we describe a totaly new mechanism of gene down-regulation in acute promyelocytic leukemia mediated by the PML/RARa fusion protein.
V této práci popisujeme zcela nový mechanismus patologického utlumení genové exprese u akutní promyelocytární leukémie fúzním proteinem PML/RARa.
Permanent Link: http://hdl.handle.net/11104/0144985
Number of the records: 1