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Biocompatibility of colloidal polypyrrole
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SYSNO ASEP 0583313 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biocompatibility of colloidal polypyrrole Author(s) Kacerova, S. (CZ)
Víchová, Z. (CZ)
Valaskova, K. (CZ)
Vícha, J. (CZ)
Münster, L. (CZ)
Kašpárková, V. (CZ)
Vašíček, Ondřej (BFU-R) ORCID, RID
Humpolíček, P. (CZ)Number of authors 8 Article number 113605 Source Title Colloids and Surfaces B-Biointerfaces. - : Elsevier - ISSN 0927-7765
Roč. 232, December 2023 (2023)Number of pages 10 s. Publication form Online - E Language eng - English Country NL - Netherlands Keywords antioxidant activity ; conducting polymers ; polyaniline ; polymerization ; nanoparticles ; cytotoxicity ; dispersions Subject RIV BO - Biophysics OECD category Biophysics Method of publishing Limited access Institutional support BFU-R - RVO:68081707 UT WOS 001102656700001 EID SCOPUS 85175161602 DOI 10.1016/j.colsurfb.2023.113605 Annotation The excellent electroconductive properties of polypyrrole (PPy) predetermine its use as cell-instructive or bio-sensing biomaterial. PPy has potential for application in a physiological environment, and here the cytotoxicity, antioxidant capacity, modulation of neutrophil oxidative burst, antibacterial activity of colloidal PPy stabilized with polyvinylpyrrolidone (PVP), and long-term stability under physiological conditions are reported. Besides, long-term stability under physiological conditions is also provided. The formation of PPy/PVP colloid was proven by UV-Vis and IR spectroscopy, and its morphology and particle size were detected. The results of cytotoxicity studies show that the safe PPy concentration in colloidal particles for biomedical usage is <= 200 mu g mL-1. In these concentrations, the PPy/PVP also exhibits excellent antioxidant properties and modulates the immune response. The minimal inhibitory concentration of 234 mu g mL-1 was determined against Staphylococcus aureus and Escherichia coli, respectively. The low cytotoxicity and bioactivity of the colloidal PPy/PVP demonstrate their long-term potential for a variety of applications Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2024 Electronic address https://www.sciencedirect.com/science/article/pii/S0927776523004836?via%3Dihub
Number of the records: 1