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Modelling the role of membrane mechanics in cell adhesion on titanium oxide nanotubes
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SYSNO ASEP 0583165 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Modelling the role of membrane mechanics in cell adhesion on titanium oxide nanotubes Author(s) Daniel, M. (CZ)
Filipič, K.E. (CZ)
Filová, Eva (UEM-P) RID, ORCID
Fojt, J. (CZ)Source Title Computer methods in biomechanics and biomedical engineering - ISSN 1025-5842
Roč. 26, č. 3 (2023), s. 281-290Number of pages 10 s. Language eng - English Country US - United States Keywords titanium ; nanotubes ; biomechanics ; adhesion ; surface energy ; cell membrane ; bending OECD category Biophysics R&D Projects GA16-14758S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UEM-P - RVO:68378041 UT WOS 000778467000001 EID SCOPUS 85128231530 DOI 10.1080/10255842.2022.2058875 Annotation
Titanium surface treated with titanium oxide nanotubes was used in many studies to quantify the effect of surface topography on cell fate. However, the predicted optimal diameter of nanotubes considerably differs among studies. We propose a model that explains cell adhesion to a nanostructured surface by considering the deformation energy of cell protrusions into titanium nanotubes and the adhesion to the surface. The optimal surface topology is defined as a geometry that gives the membrane a minimum energy shape. A dimensionless parameter, the cell interaction index, was proposed to describe the interplay between the cell membrane bending, the intrinsic curvature, and the strength of cell adhesion. Model simulation shows that an optimal nanotube diameter ranging from 20 nm to 100 nm (cell interaction index between 0.2 and 1, respectively) is feasible within a certain range of parameters describing cell membrane adhesion and bending. The results indicate a possibility to tune the topology of a nanostructural surface in order to enhance the proliferation and differentiation of cells mechanically compatible with the given surface geometry while suppressing the growth of other mechanically incompatible cells.Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2024 Electronic address https://www.tandfonline.com/doi/full/10.1080/10255842.2022.2058875
Number of the records: 1