Number of the records: 1

３’３’－環状ジヌクレオチドおよびそのプロドラッグ

SYSNO ASEP	0580625
Document Type	P - Patent
R&D Document Type	Patent or other outcome protected by special legislation
Title	３’３’－環状ジヌクレオチドおよびそのプロドラッグ
Title	3'3'-cyclic dinucleotides and prodrugs thereof
Author(s)	Birkuš, Gabriel (UOCHB-X)_ORCID Páv, Ondřej (UOCHB-X)_{RID, ORCID} Břehová, Petra (UOCHB-X)_{RID, ORCID} Šimák, Ondřej (UOCHB-X)_RID
Year of issue	2023
Possible third party use of the result	A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence
Royalty requested	A - Poskytovatel licence požaduje licenční poplatek
Patent no. or utility model no. or industrial design no.	JP7350872
Date of the patent acceptance	26.09.2023
Name of the patent owner	Ústav organické chemie a biochemie AV ČR, v. v. i.
Code of the issuer name	JP001 - Japan Patent Office (JPO) Tokyo
Current use	A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem
Territorial Protection	NEU - národní patent v zemi mimo EU PCT - mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci
Language	jpn - Japanese
Keywords	STING ; cyclic dinucleotide ; oncology
OECD category	Medicinal chemistry
R&D Projects	EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UOCHB-X - RVO:61388963
Annotation	本開示は、一般式（Ｉ）の３’３’環状ホスホネートジヌクレオチド、それらの薬学的に許容可能な塩、それらの薬学的組成物、および前記物質と他の医薬品または医薬との組み合わせに関する。本開示はまた、ＳＴＩＮＧタンパク質調節によって改変可能な疾患または状態（例えば、癌またはウイルス、アレルギー性および炎症性疾患）の治療または予防のための前記化合物の使用に関する。さらに、これらの物質は、ワクチンにおけるアジュバントとして使用され得る。【化１】
Description in English	The present disclosure relates to 3'3' cyclic phosphonate dinucleotides of general formula (I), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2024
Electronic address	https://worldwide.espacenet.com/patent/search/family/069845483/publication/JP7350872B2?q=JP7350872B2

Number of the records: 1