Interictal invasive very high-frequency oscillations in resting awake state and sleep

0579364 - ÚPT 2024 RIV US eng J - Journal Article
Revajová, K. - Trávníček, Vojtěch - Jurák, Pavel - Vašíčková, Zuzana - Halámek, Josef - Klimeš, Petr - Cimbálník, J. - Brázdil, M. - Pail, M.
Interictal invasive very high-frequency oscillations in resting awake state and sleep.
Scientific Reports. Roč. 13, č. 1 (2023), č. článku 19225. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA MŠMT(CZ) LX22NPO5107; GA ČR(CZ) GA22-28784S; GA MZd(CZ) NU22-08-00278
Institutional support: RVO:68081731
Keywords : very high‑frequency oscillations (VHFOs) * epilepsy * stereoencephalography
OECD category: Neurosciences (including psychophysiology
Impact factor: 4.6, year: 2022
Method of publishing: Open access
https://www.nature.com/articles/s41598-023-46024-z

Interictal very high-frequency oscillations (VHFOs, 500-2000Hz) in a resting awake state seem to be, according to a precedent study of our team, a more specific predictor of a good outcome of the epilepsy surgery compared to traditional interictal high-frequency oscillations (HFOs, 80-500Hz). In this study, we retested this hypothesis on a larger cohort of patients. In addition, we also collected patients' sleep data and hypothesized that the occurrence of VHFOs in sleep will be greater than in resting state. We recorded interictal invasive electroencephalographic (iEEG) oscillations in 104 patients with drug-resistant epilepsy in a resting state and in 35 patients during sleep. 21 patients in the rest study and 11 patients in the sleep study met the inclusion criteria (interictal HFOs and VHFOs present in iEEG recordings, a surgical intervention and a postoperative follow-up of at least 1year) for further evaluation of iEEG data. In the rest study, patients with good postoperative outcomes had significantly higher ratio of resected contacts with VHFOs compared to HFOs. In sleep, VHFOs were more abundant than in rest and the percentage of resected contacts in patients with good and poor outcomes did not considerably differ in any type of oscillations. In conclusion, (1) our results confirm, in a larger patient cohort, our previous work about VHFOs being a specific predictor of the area which needs to be resected, and (2) that more frequent sleep VHFOs do not further improve the results.
Permanent Link: https://hdl.handle.net/11104/0348200