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Combined effects of valproate and naringin on kidney antioxidative markers and serum parameters of kidney function in C57BL6 mice
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SYSNO ASEP 0577357 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Combined effects of valproate and naringin on kidney antioxidative markers and serum parameters of kidney function in C57BL6 mice Author(s) Jutrić, D. (HR)
Dikić, D. (HR)
Boroš, Almoš (FGU-C)
Odeh, D. (HR)
Gračan, R. (HR)
Beletić, A. (HR)
Jurčević, I. L. (HR)Source Title Arhiv za Higijenu Rada i Toksikologiju - ISSN 0004-1254
Roč. 74, č. 3 (2023), s. 218-223Number of pages 6 s. Language eng - English Country HR - Croatia Keywords calcium ; catalase ; hyperkalaemia ; malondialdehyde ; oxidative stress ; potassium ; sodium ; superoxide dismutase OECD category Physiology (including cytology) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 001080694100007 EID SCOPUS 85174520405 DOI 10.2478/aiht-2023-74-3764 Annotation Valproate is known to disturb the kidney function, and high doses or prolonged intake may cause serum ion imbalance, kidney tubular acidosis, proteinuria, hyperuricosuria, polyuria, polydipsia, and dehydration. The aim of this in vivo study was to see whether naringin would counter the adverse effects of high-dose valproate in C57Bl/6 mice and to which extent. As expected, valproate (150 mg/kg bw a day for 10 days) caused serum hyperkalaemia, more in male than female mice. Naringin reversed (25 mg/kg bw a day for 10 days) the hyperkalaemia and activated antioxidative defence mechanisms (mainly catalase and glutathione), again more efficiently in females. In males naringin combined with valproate was not as effective and even showed some prooxidative effects. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2024 Electronic address https://doi.org/10.2478/aiht-2023-74-3764
Number of the records: 1