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Biomarkers for Huntington's Disease
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SYSNO ASEP 0577188 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Mitochondrial/Oxidative Stress Biomarkers in Huntington’s Disease Author(s) Vodičková Kepková, Kateřina (UZFG-Y) ORCID
Vodička, Petr (UZFG-Y) ORCIDSource Title Biomarkers for Huntington's Disease. - Cham : Springer, 2023 / Thomas E. A. ; Parkin G. M. - ISBN 978-3-031-32814-5 Pages s. 321-350 Number of pages 30 s. Number of copy 1000 Number of pages 475 Publication form Print - P Language eng - English Country CH - Switzerland Keywords oxidative stress ; Huntington´s disease Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects GA22-24983S GA ČR - Czech Science Foundation (CSF) Institutional support UZFG-Y - RVO:67985904 DOI 10.1007/978-3-031-32815-2_13 Annotation Huntington’s disease (HD) is a hereditary neurodegeneration caused by a mutation in the HTT gene, leading to mutated huntingtin protein aggregation. This results in a widespread dysregulation of cellular pathways and death of medium spiny neurons of the striatum. Due to the high metabolic demand of brain tissue, mitochondrial dysfunction and resulting oxidative stress are common pathological features contributing to many neurodegenerative diseases, including HD. In this review, we summarize studies that measured fluid biomarkers of oxidative stress in HD patients. At the current state of knowledge, none of the reviewed biomarkers can be used as a reliable measure of HD progression or response to treatment in isolation. However, combining biomarkers covering different aspects of mitochondrial dysfunction and oxidative stress with HD specific biomarkers could be a more promising strategy. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2024
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