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Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells
- 1.0566824 - ÚOCHB 2024 RIV NL eng J - Journal Article
Lirussi, F. - Pyrshev, K. - Yesylevskyy, Semen - Rivel, T. - Lopez, T. - Coppens, E. - Mura, S. - Couvreur, P. - Ramseyer, C.
Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells.
Biochimica Et Biophysica Acta-Molecular Basis of Disease. Roč. 1869, č. 2 (2023), č. článku 166614. ISSN 0925-4439. E-ISSN 1879-260X
Institutional support: RVO:61388963
Keywords : gemcitabine-squalene * nanomedicine * lipid composition * selective delivery * plasma membrane * cancer targeting
OECD category: Physical chemistry
Impact factor: 6.2, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.bbadis.2022.166614
Up to now the lipid bilayers were rarely considered as targets in cancer therapy despite pronounced differences in lipid composition between plasma membranes of benign and malignant cells. In this study we demonstrate that the lipid bilayer of the plasma membrane is druggable and suitable for facilitating selective delivery of amphiphilic gemcitabine-squalene nanomedicines to cancer cells. Data from radioactive assays, fluorescent membrane probes and molecular dynamics simulations provide evidence of selective accumulation of gemcitabine-squalene in the plasma membranes with disrupted lipid asymmetry and its subsequent preferential uptake by malignant cells. This causes pronounced cytotoxicity on cancer cells in comparison to their benign counterparts originating from the same tissue.
Permanent Link: https://hdl.handle.net/11104/0338101
Number of the records: 1