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Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections
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SYSNO ASEP 0565986 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections Author(s) Paprčková, Darina (UMG-J) ORCID, RID
Niederlová, Veronika (UMG-J) ORCID
Moudrá, Alena (UMG-J)
Drobek, Aleš (UMG-J) ORCID
Přibíková, Michaela (UMG-J)
Janušová, Šárka (UMG-J) ORCID
Schober, K. (DE)
Neuwirth, Aleš (UMG-J) ORCID
Michálik, Juraj (UMG-J) ORCID
Huranová, Martina (UMG-J) ORCID
Horková, Veronika (UMG-J) ORCID
Cesneková, Michaela (UMG-J)
Šímová, Michaela (UMG-J)
Procházka, Jan (UMG-J) ORCID
Balounová, Jana (UMG-J)
Busch, D. H. (DE)
Sedláček, Radislav (UMG-J) RID
Schwarzer, Martin (MBU-M) ORCID, RID
Štěpánek, Ondřej (UMG-J) RID, ORCIDNumber of authors 19 Article number 1009198 Source Title Frontiers in Immunology. - : Frontiers Media - ISSN 1664-3224
Roč. 13, 6 Oct (2022)Number of pages 14 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords T cell ; self-reactivity ; antigen-inexperienced memory-like CD8 T cells ; T-cell diversity ; interferon response Subject RIV EB - Genetics ; Molecular Biology OECD category Immunology R&D Projects GJ19-03435Y GA ČR - Czech Science Foundation (CSF) GM21-19640M GA ČR - Czech Science Foundation (CSF) LM2015040 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2018126 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED2.1.00/19.0395 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LX22NPO5103 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Research Infrastructure CCP - 90040 - Ústav molekulární genetiky AV ČR, v. v. i.
CCP II - 90126 - Ústav molekulární genetiky AV ČR, v. v. i.Method of publishing Open access Institutional support UMG-J - RVO:68378050 ; MBU-M - RVO:61388971 UT WOS 000874521100001 DOI 10.3389/fimmu.2022.1009198 Annotation Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reactivity in T-cell biology is incompletely understood. We addressed the role of self-reactivity in T-cell diversity by generating an atlas of mouse peripheral CD8(+) T cells, which revealed two unconventional populations of antigen-inexperienced T cells. In the next step, we examined the steady-state phenotype of monoclonal T cells with various levels of self-reactivity. Highly self-reactive clones preferentially differentiate into antigen-inexperienced memory-like cells, but do not form a population expressing type I interferon-induced genes, showing that these two subsets have unrelated origins. The functional comparison of naive monoclonal CD8(+) T cells specific to the identical model antigen did not show any correlation between the level of self-reactivity and the magnitude of the immune response. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2023 Electronic address https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009198/full
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