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Voltammetric study of new psychoactive substance 3-fluorophenmetrazine
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SYSNO ASEP 0557347 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Voltammetric study of new psychoactive substance 3-fluorophenmetrazine Author(s) Jiroušková, Eliška (UFCH-W)
Čabala, R. (CZ)
Sokolová, Romana (UFCH-W) RID, ORCID, SAIArticle number e2100223 Source Title Electrochemical Science Advances. - : Wiley - ISSN 2698-5977
Roč. 3, č. 5 (2023)Number of pages 10 s. Language eng - English Country DE - Germany Keywords 3-fluorophenmetrazine ; cyclic voltammetry ; differential pulse voltammetry ; HOMO/LUMOspatial distribution ; IR spectroelectrochemistry Subject RIV CG - Electrochemistry OECD category Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis) R&D Projects GA19-03160S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UFCH-W - RVO:61388955 UT WOS 001134957800003 EID SCOPUS 85173072555 DOI 10.1002/elsa.202100223 Annotation Electrochemical oxidation of the new psychoactive substance 3-fluorophenmetrazine (FPM) was studied in phosphate buffers by cyclic voltammetry and differential pulse voltammetry (DPV) on a glassy carbon electrode. The redox potential of FPM in buffered solution strongly depends on pH. Cyclic voltammetry behavior shows the partial influence of adsorption on the electrode process not allowing detailed analysis of the individual steps of the reaction scheme, it means the involvement of electron transfer (E) and chemical reaction (C). Nevertheless, the irreversible shape of the cyclic voltammogram is explained by the participation of hydroxylation nucleophilic addition of water (hydroxylation) after two-electron/two-proton oxidation of molecule at the tetrahydro-1,4-oxazine ring. The suggested mechanism leading to hydroxylated derivative 2-(3-fluorophenyl)-3-methyl-5-hydroxymorfolin is supported by the calculated highest occupied molecular orbital spatial distribution and atomic charges calculations for electrochemically formed radical cation. Infrared spectroelectrochemistry performed during oxidation in acetonitrile/water also supported the formation of this product.
The analytical method of FPM determination on glassy carbon electrode was developed using DPV with an attained limit of detection = 4.7 μmol/L in phosphate buffer of pH 9. The linear range of the calibration curve is from 7.0 to 107.00 μmol/L, correlation coefficient (r) = 0.9988.
Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2024 Electronic address http://hdl.handle.net/11104/0331384
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