Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects.

0553682 - ÚCHP 2023 RIV CH eng J - Journal Article
Edr, Antonín - Wróbel, D. - Krupková, Alena - Červenková Šťastná, Lucie - Cuřínová, Petra - Novák, A. - Malý, J. - Kalasová, J. - Malý, M. - Strašák, Tomáš
Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects.
International Journal of Molecular Sciences. Roč. 23, č. 4 (2022), č. článku 2114. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) LTC19049
EU Projects: European Commission(XE) CA17140 - COST Action
Institutional support: RVO:67985858
Keywords : carbosilane * dendrons * amphiphiles
OECD category: Organic chemistry
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1422-0067/23/4/2114

Supramolecular structures, such as micelles, liposomes, polymerosomes or dendrimerosomes, are widely studied and used as drug delivery systems. The behavior of amphiphilic building blocks strongly depends on their spatial distribution and shape of polar and nonpolar component. This report is focused on the development of new versatile synthetic protocols for amphiphilic carbosilane dendrons (amp‐CS‐DDNs) capable of self‐assembly to regular micelles and other supramolecular objects. The presented strategy enables the fine modification of amphiphilic structure in several ways and also enables the facile connection of a desired functionality. DLS experiments demonstrated correlations between structural parameters of amp‐CS‐DDNs and the size of formed nanoparticles. For detailed information about the organization and spatial distribution of amp‐CS‐DDNs assemblies, computer simulation models were studied by using molecular dynamics in explicit water.
Permanent Link: http://hdl.handle.net/11104/0328427