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Morphological and Hemodynamic Changes during Cerebral Aneurysm Growth
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SYSNO ASEP 0553039 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Morphological and Hemodynamic Changes during Cerebral Aneurysm Growth Author(s) Nordahl, E.R. (US)
Uthamaraj, S. (US)
Dennis, K.D. (US)
Sejkorová, A. (CZ)
Hejčl, Aleš (UEM-P) RID, ORCID
Hron, J. (CZ)
Svihlová, H. (CZ)
Carlson, K.D. (US)
Suzen, Y.B. (US)
Dragomir-Daescu, D. (US)Article number 520 Source Title Brain Sciences. - : MDPI
Roč. 11, č. 4 (2021)Number of pages 10 s. Language eng - English Country CH - Switzerland Keywords hemodynamics ; aneurysm growth ; computational fluid dynamics ; oscillatory shear index ; wall shear stress ; kinetic energy Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000642782300001 EID SCOPUS 85105002936 DOI 10.3390/brainsci11040520 Annotation Computational fluid dynamics (CFD) has grown as a tool to help understand the hemodynamic properties related to the rupture of cerebral aneurysms. Few of these studies deal specifically with aneurysm growth and most only use a single time instance within the aneurysm growth history. The present retrospective study investigated four patient-specific aneurysms, once at initial diagnosis and then at follow-up, to analyze hemodynamic and morphological changes. Aneurysm geometries were segmented via the medical image processing software Mimics. The geometries were meshed and a computational fluid dynamics (CFD) analysis was performed using ANSYS. Results showed that major geometry bulk growth occurred in areas of low wall shear stress (WSS). Wall shape remodeling near neck impingement regions occurred in areas with large gradients of WSS and oscillatory shear index. This study found that growth occurred in areas where low WSS was accompanied by high velocity gradients between the aneurysm wall and large swirling flow structures. A new finding was that all cases showed an increase in kinetic energy from the first time point to the second, and this change in kinetic energy seems correlated to the change in aneurysm volume. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2022 Electronic address https://www.mdpi.com/2076-3425/11/4/520
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