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Carbon-based nanomaterials increase reactivity of primary monocytes towards various bacteria and modulate their differentiation into macrophages
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SYSNO ASEP 0548780 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Carbon-based nanomaterials increase reactivity of primary monocytes towards various bacteria and modulate their differentiation into macrophages Author(s) Švadláková, T. (CZ)
Koláčková, M. (CZ)
Vaňková, R. (CZ)
Karakale, R. (CZ)
Málková, A. (CZ)
Kulich, P. (CZ)
Hubatka, F. (CZ)
Turanek-Knotigová, P. (CZ)
Kratochvílová, Irena (FZU-D) RID, ORCID, SAI
Raška, M. (CZ)
Krejsek, J. (CZ)
Turánek, Jaroslav (FZU-D)Number of authors 12 Article number 2510 Source Title Nanomaterials. - : MDPI
Roč. 11, č. 10 (2021)Number of pages 17 s. Language eng - English Country CH - Switzerland Keywords graphene ; carbon nanotubes ; cytotoxicity Subject RIV BO - Biophysics OECD category Biophysics R&D Projects EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FZU-D - RVO:68378271 UT WOS 000712617400001 EID SCOPUS 85115798763 DOI 10.3390/nano11102510 Annotation The evaluation of carbon-based nanomaterials’ (C-BNMs’) interactions with the immune system, notably their ability to cause inflammation, is a critical step in C-BNM health risk assessment. Particular attention should be given to those C-BNMs that do not cause direct cytotoxicity or inflammation on their own. However, the intracellular presence of these non-biodegradable nanomaterials could dysregulate additional cell functions. This is even more crucial in the case of phagocytes, which are the main mediators of defensive inflammation towards pathogens. Hence, our study was focused on multi-walled carbon nanotubes (MWCNTs) and two different types of graphene platelets (GPs) and whether their intracellular presence modulates a proinflammatory response from human primary monocytes towards common pathogens. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2022 Electronic address http://hdl.handle.net/11104/0324954
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