Number of the records: 1
Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art
- 1.
SYSNO ASEP 0547183 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art Author(s) Chaudhary, P. (IE)
Milluzzo, G. (IE)
Ahmed, H. (IE)
Odložilík, Boris (FZU-D) ORCID
McMurray, A. (IE)
Prise, K. M. (IE)
Borghesi, M. (IE)Number of authors 7 Article number 624963 Source Title Frontiers in Physics. - : Frontiers Research Foundation - ISSN 2296-424X
Roč. 9, Apr (2021)Number of pages 12 s. Language eng - English Country CH - Switzerland Keywords protontherapy ; cancer ; radiobiology ; laser-driven ions ; particle accelerator ; ultra-high dose rate Subject RIV BL - Plasma and Gas Discharge Physics OECD category Fluids and plasma physics (including surface physics) Research Infrastructure ELI Beamlines III - 90141 - Fyzikální ústav AV ČR, v. v. i. Method of publishing Open access Institutional support FZU-D - RVO:68378271 UT WOS 000642239200001 EID SCOPUS 85104594063 DOI 10.3389/fphy.2021.624963 Annotation The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index. Recent studies show that normal tissue sparing can be further enhanced through proton delivery at 100 Gy/s and above, in the so-called FLASH regime. This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. An extensive investigation of the radiobiology of laser-driven protons is therefore not only necessary for future clinical application, but also offers the opportunity of accessing yet untested regimes of radiobiology. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2022 Electronic address http://hdl.handle.net/11104/0323523
Number of the records: 1