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Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus
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SYSNO ASEP 0544467 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus Author(s) Deutschová, B. (CZ)
Klimeš, Petr (UPT-D) RID, ORCID, SAI
Jordan, Z. (HU)
Jurák, Pavel (UPT-D) RID, ORCID, SAI
Erőss, L. (HU)
Lamoš, M. (CZ)
Halámek, Josef (UPT-D) RID, ORCID, SAI
Daniel, P. (CZ)
Rektor, I. (CZ)
Fabo, D. (HU)Number of authors 10 Source Title Epilepsia. - : Wiley - ISSN 0013-9580
Roč. 62, č. 5 (2021), E70-E75Number of pages 6 s. Publication form Print - P Language eng - English Country US - United States Keywords anterior thalamic nucleus ; deep brain stimulation ; oscillations ; prediction Subject RIV FH - Neurology OECD category Clinical neurology R&D Projects GA21-25953S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UPT-D - RVO:68081731 UT WOS 000631593800001 EID SCOPUS 85102899032 DOI 10.1111/epi.16883 Annotation We hypothesized that local/regional properties of stimulated structure/circuitry contribute to the effect of deep brain stimulation (DBS). We analyzed intracerebral electroencephalographic (EEG) recordings from externalized DBS electrodes targeted bilaterally in the anterior nuclei of the thalamus (ANT) in 12 patients (six responders, six nonresponders) with more than 1 year of follow-up care. In the bipolar local field potentials of the EEG, spectral power (PW) and power spectral entropy (PSE) were calculated in the passbands 1-4, 4-8, 8-12, 12-20, 20-45, 65-80, 80-200 and 200-500 Hz. The most significant differences between responders and nonresponders were observed in the BRIDGE area (bipolar recordings with one contact within the ANT and the second contact in adjacent tissue). In responders, PW was significantly decreased in the frequency bands of 65-80, 80-200, and 200-500 Hz (p < .05), PSE was significantly increased in all frequency bands (p < .05) except for 200-500 Hz (p = .06). The local EEG characteristics of ANT recorded after implantation may play a significant role in DBS response prediction. Workplace Institute of Scientific Instruments Contact Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Year of Publishing 2022 Electronic address https://onlinelibrary.wiley.com/doi/10.1111/epi.16883
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