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Cytoskeletal organization through multivalent interactions
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SYSNO ASEP 0541339 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cytoskeletal organization through multivalent interactions Author(s) Braun, Marcus (BTO-N) ORCID
Diez, S. (DE)
Lánský, Zdeněk (BTO-N)Number of authors 3 Article number jcs234393 Source Title Journal of Cell Science. - : Company of Biologists - ISSN 0021-9533
Roč. 133, č. 12 (2020)Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords Cytoskeletal self-organization ; Microtubuleassociated protein ; Protein avidity Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects GX19-27477X GA ČR - Czech Science Foundation (CSF) GA20-04068S GA ČR - Czech Science Foundation (CSF) ED2.1.00/19.0390 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support BTO-N - RVO:86652036 UT WOS 000546341900006 EID SCOPUS 85086620098 DOI 10.1242/jcs.234393 Annotation The cytoskeleton consists of polymeric protein filaments with periodic lattices displaying identical binding sites, which establish a multivalent platform for the binding of a plethora of filament-associated ligand proteins. Multivalent ligand proteins can tether themselves to the filaments through one of their binding sites, resulting in an enhanced reaction kinetics for the remaining binding sites. In this Opinion, we discuss a number of cytoskeletal phenomena underpinned by such multivalent interactions, namely (1) generation of entropic forces by filament crosslinkers, (2) processivity of molecular motors, (3) spatial sorting of proteins, and (4) concentration-dependent unbinding of filament-associated proteins. These examples highlight that cytoskeletal filaments constitute the basis for the formation of microenvironments, which cytoskeletal ligand proteins can associate with and, once engaged, can act within at altered reaction kinetics. We thus argue that multivalency is one of the properties crucial for the functionality of the cytoskeleton. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2021 Electronic address https://jcs.biologists.org/content/133/12/jcs234393
Number of the records: 1