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Chiral Nafion membranes prepared by strong electrostatic binding of multiply positively charged β-cyclodextrin derivatives for tryptophan racemic mixtures’ separation.
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SYSNO ASEP 0541140 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chiral Nafion membranes prepared by strong electrostatic binding of multiply positively charged β-cyclodextrin derivatives for tryptophan racemic mixtures’ separation. Author(s) Kasal, P. (CZ)
Michel, Marine (UCHP-M)
Gaálová, Jana (UCHP-M) RID, SAI, ORCID
Cuřínová, Petra (UCHP-M) RID, SAI, ORCID
Izák, Pavel (UCHP-M) RID, ORCID, SAI
Jindřich, J. (CZ)Article number 102234 Source Title Materials Today Communications. - : Elsevier - ISSN 2352-4928
Roč. 27, JUN 2021 (2021)Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords optical resolution ; cyclodextrins ; racemic mixtures Subject RIV CI - Industrial Chemistry, Chemical Engineering OECD category Chemical process engineering R&D Projects GA20-09980S GA ČR - Czech Science Foundation (CSF) FV10082 GA MPO - Ministry of Industry and Trade (MPO) Method of publishing Open access with time embargo (01.07.2023) Institutional support UCHP-M - RVO:67985858 UT WOS 000683034600005 EID SCOPUS 85102622535 DOI 10.1016/j.mtcomm.2021.102234 Annotation Three multiply positively charged β-cyclodextrin derivatives were prepared and ionically bound to a Nafion® 117 membrane. The derivatives differed only in the length of the linker, which connects the positively charged anchor to the cyclodextrin moiety. The resulting membranes exert preferential sorption of l-enantiomer of tryptophan from its racemic mixture (ee reaching 44 % for the medium linker length). The membrane follows the retarded transport mechanism. Using a fluorophore-tagged cyclodextrin modifier, we confirmed no leaching of the modifier from the membrane. Thus, we proved the potential of the approach of electrostatic binding of chiral selectors for the enantioseparation of chiral drugs. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2022 Electronic address http://hdl.handle.net/11104/0318741
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