Translational Research in Serious Human Diseases

0536624 - ÚŽFG 2021 RIV CZ eng M - Monography Chapter
Knoblochová, Lucie - Šolc, Petr
DNA damage response signalling and cell cycle checkpoint activation in regular and aberrant cell cycle progression.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 238-243. ISBN 978-80-200-3158-7
R&D Projects: GA MŠMT(CZ) LO1609; GA ČR(CZ) GA20-27742S
Institutional support: RVO:67985904
Keywords : DNA damage response * S-phase checkpoint * G2/M checkpoint
OECD category: Cell biology

DNA damage response signalling and cell cycle checkpoint activation guard against genome instability, which can be detrimental for cellular development. The purpose of the DNA damage response signalling pathway is to slow down cell cycle progression by the activation of cell cycle checkpoint signalling to provide time for repairing of DNA damage. This chapter is concerned with the molecular characterization of these pathways.
Permanent Link: http://hdl.handle.net/11104/0314371