Could Global Intensification of Nitrogen Fertilisation Increase Immunogenic Proteins and Favour the Spread of Coeliac Pathology?

Penuelas, Josep; Gargallo-Garriga, Albert; Janssens, I. A.; Ciais, P.; Obersteiner, P.; Klem, Karel; Urban, Otmar; Zhu, Y.G.; Sardans, Jordi

doi:https://dx.doi.org/10.3390/foods9111602

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Could Global Intensification of Nitrogen Fertilisation Increase Immunogenic Proteins and Favour the Spread of Coeliac Pathology?

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SYSNO ASEP	0536353
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Could Global Intensification of Nitrogen Fertilisation Increase Immunogenic Proteins and Favour the Spread of Coeliac Pathology?
Author(s)	Penuelas, Josep (UEK-B)_{ORCID, SAI, RID} Gargallo-Garriga, Albert (UEK-B)_{ORCID, SAI, RID} Janssens, I. A. (BE) Ciais, P. (FR) Obersteiner, P. (AT) Klem, Karel (UEK-B)_{RID, ORCID, SAI} Urban, Otmar (UEK-B)_{RID, ORCID, SAI} Zhu, Y.G. (CN) Sardans, Jordi (UEK-B)_{ORCID, RID, SAI}
Number of authors	9
Article number	1602
Source Title	Foods. - : MDPI Roč. 9, č. 11 (2020)
Number of pages	21 s.
Language	eng - English
Country	CH - Switzerland
Keywords	bread-making quality ; environmentally-induced changes ; amino-acid-composition ; durum-wheat ; winter-wheat ; grain-yield ; omega-gliadins ; spring wheat ; technological quality ; nutritional-value ; global intensification of N fertilisation ; wheat ; allergenic proteins ; gluten proteins ; coeliac pathology
Subject RIV	GM - Food Processing
OECD category	Agriculture
R&D Projects	EF16_019/0000797 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	UEK-B - RVO:86652079
UT WOS	000594006500001
DOI	10.3390/foods9111602
Annotation	Fertilisation of cereal crops with nitrogen (N) has increased in the last five decades. In particular, the fertilisation of wheat crops increased by nearly one order of magnitude from 1961 to 2010, from 9.84 to 93.8 kg N ha(-1) y(-1). We hypothesized that this intensification of N fertilisation would increase the content of allergenic proteins in wheat which could likely be associated with the increased pathology of coeliac disease in human populations. An increase in the per capita intake of gliadin proteins, the group of gluten proteins principally responsible for the development of coeliac disease, would be the responsible factor. We conducted a global meta-analysis of available reports that supported our hypothesis: wheat plants growing in soils receiving higher doses of N fertilizer have higher total gluten, total gliadin, alpha/beta-gliadin, gamma-gliadin and omega-gliadin contents and higher gliadin transcription in their grain. We thereafter calculated the per capita annual average intake of gliadins from wheat and derived foods and found that it increased from 1961 to 2010 from approximately 2.4 to 3.8 kg y(-1) per capita (+1.4 +/- 0.18 kg y(-1) per capita, mean +/- SE), i.e., increased by 58 +/- 7.5%. Finally, we found that this increase was positively correlated with the increase in the rates of coeliac disease in all the available studies with temporal series of coeliac disease. The impacts and damage of over-fertilisation have been observed at an environmental scale (e.g., eutrophication and acid rain), but a potential direct effect of over-fertilisation is thus also possible on human health (coeliac disease).
Workplace	Global Change Research Institute
Contact	Nikola Šviková, svikova.n@czechglobe.cz, Tel.: 511 192 268
Year of Publishing	2021
Electronic address	https://www.mdpi.com/2304-8158/9/11/1602

Number of the records: 1