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Nano-in-Micro Dual Delivery Platform for Chronic Wound Healing Applications
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SYSNO ASEP 0523852 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nano-in-Micro Dual Delivery Platform for Chronic Wound Healing Applications Author(s) Zárubová, Jana (FGU-C) RID, ORCID
Hasani-Sadrabadi, M. M. (US)
Bačáková, Lucie (FGU-C) RID, ORCID
Li, S. (US)Article number 158 Source Title Micromachines. - : MDPI
Roč. 11, č. 2 (2020)Number of pages 12 s. Language eng - English Country CH - Switzerland Keywords chronic wounds ; angiogenesis ; antibacterial properties ; drug delivery ; microfluidics ; nanoparticles ; microparticles Subject RIV EI - Biotechnology ; Bionics OECD category Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction) R&D Projects LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000520181500047 EID SCOPUS 85081159618 DOI 10.3390/mi11020158 Annotation Here, we developed a combinatorial delivery platform for chronic wound healing applications. A microfluidic system was utilized to form a series of biopolymer-based microparticles with enhanced affinity to encapsulate and deliver vascular endothelial growth factor (VEGF). Presence of heparin into the structure can significantly increase the encapsulation efficiency up to 95% and lower the release rate of encapsulated VEGF. Our in vitro results demonstrated that sustained release of VEGF from microparticles can promote capillary network formation and sprouting of endothelial cells in 2D and 3D microenvironments. These engineered microparticles can also encapsulate antibiotic-loaded nanoparticles to offer a dual delivery system able to fight bacterial infection while promoting angiogenesis. We believe this highly tunable drug delivery platform can be used alone or in combination with other wound care products to improve the wound healing process and promote tissue regeneration. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://doi.org/10.3390/mi11020158
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