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Carbon Nanomaterials for Bioimaging, Bioanalysis, and Therapy
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SYSNO ASEP 0521416 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Using Polymers to Enhance the Carbon Nanomaterial Biointerface Author(s) Pramanik, Goutam (UOCHB-X) ORCID
Neburková, Jitka (UOCHB-X) RID, ORCID
Vaněk, Václav (UOCHB-X) RID, ORCID
Jani, Mona (UOCHB-X)
Kindermann, Marek (UOCHB-X)
Cígler, Petr (UOCHB-X) RID, ORCIDSource Title Carbon Nanomaterials for Bioimaging, Bioanalysis, and Therapy. - Hoboken : Wiley, 2019 / Hui Y. Y. ; Chang H.-C. ; Dong H. ; Zhang X. - ISBN 978-1-119-37345-2 Pages s. 15-42 Number of pages 28 s. Number of pages 376 Publication form Print - P Language eng - English Country US - United States Keywords biomedical applications ; carbon nanomaterials ; covalent modification ; DLVO theory ; noncovalent coating ; nucleic acids ; polymer functionalization ; stimuli‐responsive polymers Subject RIV CD - Macromolecular Chemistry OECD category Nano-materials (production and properties) R&D Projects GA18-17071S GA ČR - Czech Science Foundation (CSF) EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UOCHB-X - RVO:61388963 DOI 10.1002/9781119373476.ch2 Annotation This chapter focuses on functionalization of carbon nanomaterials (CNMs) with polymers for biomedical applications. A classical theoretical approach based on Derjaguin‐Landau‐Verwey‐Overbeek (DLVO) theory is commonly used to predict the stability of a colloidal system. CNMs can be functionalized with polymers via two types of approaches: noncovalent coating and covalent modification. The physicochemical properties of CNMs are determined by their intrinsic nanostructure. The chapter discusses the effect of polymer functionalization on the spectral properties of various CNMs. Stimuli‐responsive polymers respond to their environment by changing their physical and/or chemical properties. Among stimuli‐responsive polymers, thermoresponsive polymers have been exploited most abundantly to modify carbon nanoparticles. The development of nonviral, nonimmunogenic, and biocompatible vectors for efficient intracellular transfection of nucleic acids (NAs) is one of the challenges facing future gene therapy approaches. The surface of the CNMs can be functionalized by covalent or noncovalent attachment of macromolecular layers to create reliable nonviral gene delivery vectors. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2020
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