Toxicity of TiO2, ZnO, and SiO2 Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials.

0506490 - ÚFCH JH 2020 RIV CH eng J - Journal Article
Remzová, Monika - Žouželka, Radek - Brzicová, Táňa - Vrbová, Kristýna - Pinkas, Dominik - Rössner ml., Pavel - Topinka, Jan - Rathouský, Jiří
Toxicity of TiO2, ZnO, and SiO2 Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials.
Nanomaterials. Roč. 9, č. 7 (2019), č. článku 968. E-ISSN 2079-4991
R&D Projects: GA MŠMT(CZ) LO1508; GA MŠMT(CZ) LM2015073; GA MŠMT(CZ) EF16_013/0001821; GA MŠMT(CZ) LM2015062; GA MŠMT(CZ) EF16_013/0001775
Institutional support: RVO:61388955 ; RVO:68378041 ; RVO:68378050
Keywords : SiO2 nanoparticles * ZnO nanoparticles * TiO2 nanoparticles
OECD category: Physical chemistry; Toxicology (UEM-P); Physical chemistry (UMG-J)
Impact factor: 4.324, year: 2019
Method of publishing: Open access

Rapid progress in the development of highly efficient nanoparticle-based construction technologies has not always been accompanied by a corresponding understanding of their effects on human health and ecosystems. In this study, we compare the toxicological effects of pristine TiO2, ZnO, SiO2, and coated SiO2 nanoparticles, and evaluate their suitability as additives to consolidants of weathered construction materials. First, water soluble tetrazolium 1 (WST-1) and lactate dehydrogenase (LDH) assays were used to determine the viability of human alveolar A549 cells at various nanoparticle concentrations (0-250 μg mL-1). While the pristine TiO2 and coated SiO2 nanoparticles did not exhibit any cytotoxic effects up to the highest tested concentration, the pristine SiO2 and ZnO nanoparticles significantly reduced cell viability. Second, as all developed nanoparticle-modified consolidants increased the mechanical strength of weathered sandstone, the decisive criterion for the selection of the most suitable nanoparticle additive was as low toxicity as possible. We believe that this approach would be of high importance in the industry, to identify materials representing top functional properties and low toxicity, at an early stage of the product development.
Permanent Link: http://hdl.handle.net/11104/0297720