MDSCs in infectious diseases: regulation, roles, and readjustment

0505122 - ÚMG 2020 RIV DE eng J - Journal Article
Dorhoi, A. - Glaria, E. - Garcia-Tellez, T. - Nieuwenhuizen, N.E. - Zelinskyy, G. - Favier, B. - Singh, A. - Ehrchen, J. - Gujer, C. - Munz, C. - Saraiva, M. - Sohrabi, Yahya - Sousa, A.E. - Delputte, P. - Mueller-Trutwin, M. - Valledor, A.F.
MDSCs in infectious diseases: regulation, roles, and readjustment.
Cancer Immunology and Immunotherapy. Roč. 68, č. 4 (2019), s. 673-685. ISSN 0340-7004. E-ISSN 1432-0851
Institutional support: RVO:68378050
Keywords : Myeloid regulatory cells * mdsc * Infection * Immunosuppression * Oncogenic viruses * Mye-EUNITER
OECD category: Immunology
Impact factor: 5.442, year: 2019
Method of publishing: Limited access
https://link.springer.com/article/10.1007/s00262-018-2277-y

Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.
Permanent Link: http://hdl.handle.net/11104/0296632