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神経保護特性を有する両親媒性化合物

SYSNO ASEP	0500385
Document Type	P - Patent
R&D Document Type	Patent or other outcome protected by special legislation
Title	神経保護特性を有する両親媒性化合物
Title	Amphiphilic compounds with neuroprotective properties
Author(s)	Kudová, Eva (UOCHB-X)_{RID, ORCID} Chodounská, Hana (UOCHB-X)_{RID, ORCID} Kapras, Vojtěch (UOCHB-X) Vyklický ml., Ladislav (FGU-C)_{RID, ORCID, SAI} Valeš, Karel (FGU-C)_{RID, ORCID, SAI} Jahn, Ullrich (UOCHB-X)_ORCID
Year of issue	2018
Possible third party use of the result	A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence
Royalty requested	A - Poskytovatel licence požaduje licenční poplatek
Patent no. or utility model no. or industrial design no.	JP6437636
Date of the patent acceptance	22.11.2018
Name of the patent owner	Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i
Code of the issuer name	JP001 - Japan Patent Office (JPO) Tokyo
Current use	A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem
Language	jpn - Japanese
Keywords	steroid ; NMDA receptor ; neuroprotective
Subject RIV	CC - Organic Chemistry
OECD category	Organic chemistry
Subject RIV - cooperation	Institute of Physiology - Pharmacology ; Medidal Chemistry
R&D Projects	TE01020028 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
	GBP304/12/G069 GA ČR - Czech Science Foundation (CSF)
Institutional support	UOCHB-X - RVO:61388963 ; FGU-C - RVO:67985823
Annotation	本発明は、神経保護効果を示す、テトラデカヒドロフェナントレン骨格を有する両親媒性化合物およびそれらのエナンチオマー、ＣＮＳの虚血性損傷、ＣＮＳの神経変性および障害などのグルタミン酸作動性神経伝達物質系の不均衡に関連する神経精神障害の治療薬としての使用、うつ病、心的外傷後ストレス障害およびストレスに関連する疾患、不安、統合失調症および精神病性障害、疼痛、中毒、多発性硬化症、てんかん、神経膠腫、ならびに前記化合物を含有する医薬組成物。
Description in English	The present invention provides amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain, addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2019
Electronic address	https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20181212&DB=&locale=en_EP&CC=JP&NR=6437636B2&KC=B2&ND=4#

Number of the records: 1