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Lipidated peptides for lowering blood glucose

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    0499645 - ÚOCHB 2019 RIV eng P - Patent Document
    Maletínská, Lenka - Železná, Blanka - Kuneš, Jaroslav - Nagelová, Veronika
    Lipidated peptides for lowering blood glucose.
    2018. Owner: Fyziologický ústav AV ČR, v. v. i. - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 17.10.2018. Patent Number: EP3094643
    R&D Projects: GA TA ČR(CZ) TE01020028
    Institutional support: RVO:61388963 ; RVO:67985823
    Keywords : prolactin-releasing peptide * lipidated * diabetes
    OECD category: Pharmacology and pharmacy; Endocrinology and metabolism (including diabetes, hormones) (FGU-C)
    https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=EP&NR=3094643B1&KC=B1&FT=D&ND=4&date=20181017&DB=&locale=en_EP

    Lipidated analogs of prolactin-releasing peptides (PrRP) and their use in controlling and lowering blood glucose in mammals is disclosed. Useful compounds included lipidated analogs of PrRP20 and PrRP31. Pharmacological effects are demonstrated both in vitro and in vivo. Peripheral administration of the lipidated analog of prolactin releasing peptide (PrRP)s lowers blood glucose levels. These treatments are applicable for treating impaired glucose tolerance (IGT), and glucose intolerance condition. The disclosed compounds have application in treating medical conditions including diabetes, pre-diabetes, eating disorders, and obesity.
    Permanent Link: http://hdl.handle.net/11104/0292013

     
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