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Disseminated Infection of Encephalitozoon cuniculi Associated with Osteolysis of Hip Periprosthetic Tissue
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SYSNO ASEP 0498716 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Disseminated Infection of Encephalitozoon cuniculi Associated with Osteolysis of Hip Periprosthetic Tissue Author(s) Kicia, M. (PL)
Wesołowska, M. (PL)
Kopacz, Z. (PL)
Kváč, Martin (BC-A) RID, RID, ORCID
Sak, Bohumil (BC-A) RID, ORCID
Sokulska, M. (PL)
Cebulski, K. (PL)
Hendrich, A. B. (PL)
Pozowski, A. (PL)Number of authors 9 Source Title Clinical Infectious Diseases. - : Oxford University Press - ISSN 1058-4838
Roč. 67, č. 8 (2018), s. 1228-1234Number of pages 7 s. Publication form Print - P Language eng - English Country US - United States Keywords Encephalitozoon cuniculi ; microsporidia ; periprosthetic joint infection ; revision hip arthroplasty Subject RIV FN - Epidemiology, Contagious Diseases ; Clinical Immunology OECD category Infectious Diseases R&D Projects GA17-12871S GA ČR - Czech Science Foundation (CSF) Institutional support BC-A - RVO:60077344 UT WOS 000446092100016 EID SCOPUS 85054213809 DOI 10.1093/cid/ciy256 Annotation Background Among patients with hip joint endoprosthesis, periprosthetic osteolysis is the most common complication following primary arthroplasty, and subsequent implant loosening is the leading cause of arthroplasty revision. Causes of stability loss, though not always evident, can be mechanical, allergic, or infectious (bacterial and fungal agents) in nature. Microsporidia, widespread opportunistic fungal pathogens that infect most human tissues, are a potential infectious cause of stability loss. Infections caused by Encephalitozoon species one of the most common microsporidial pathogens in humans primarily localize to intestinal and respiratory tracts, but can disseminate to tissues throughout the body. Methods We examined 53 immunocompetent patients, 23 after revision and 30 after primary hip arthroplasty, for infection by Encephalitozoon species. Periprosthetic tissue, urine sediments, and stool samples were tested by microscopic examination and genus-specific nested polymerase chain reaction followed by genotyping. Results Ten patients had Encephalitozoon-positive periprosthetic tissues, 9 (39%) after revision and 1 (3.3%) after primary hip arthroplasty. Among the tissue-positive postrevision patients, 7 had a positive urine sample and 1 had a positive stool sample. Encephalitozoon cuniculi genotype II was identified in 88.8% (16/18) of samples. Two urine samples were positive for a novel Encephalitozoon species. Conclusions Encephalitozoon cuniculi should be considered as a cause of osteolysis in hip periprosthetic tissue, leading to a loss of implant stability. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2019
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