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Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications
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SYSNO ASEP 0498616 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications Author(s) Vávra, Jan (UOCHB-X)
Řehoř, Ivan (UOCHB-X) RID, ORCID
Rendler, T. (DE)
Jani, Mona (UOCHB-X)
Bednár, J. (CZ)
Baksh, M. M. (US)
Zappe, A. (DE)
Wrachtrup, J. (DE)
Cígler, Petr (UOCHB-X) RID, ORCIDArticle number 1803406 Source Title Advanced Functional Materials - ISSN 1616-301X
Roč. 28, č. 45 (2018)Number of pages 9 s. Language eng - English Country DE - Germany Keywords gadolinium ; nanodiamonds ; nitrogen-vacancy centers ; spin labels ; supported lipid bilayers Subject RIV BO - Biophysics OECD category Biophysics R&D Projects GA16-16336S GA ČR - Czech Science Foundation (CSF) EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UOCHB-X - RVO:61388963 UT WOS 000449706700025 EID SCOPUS 85053494999 DOI 10.1002/adfm.201803406 Annotation Fluorescent nanodiamonds with nitrogen-vacancy (NV) centers respond to local changes in electric and magnetic fields. These responses can be read optically as changes in fluorescence. NV centers do not suffer from photoblinking or photobleaching, making nanodiamonds a viable platform for long-term imaging of processes inside living cells. However, for any bioapplication, the surface of these particles must be modified to prevent aggregation and nonspecific protein adsorption and to effectively transduce the changes in local environment to NV center. Modular biomimetic interface has been developed on nanodiamonds with remarkable sensitivity for relaxometric readout that takes advantage of self-assembled phospholipid bilayers supported by the nanoparticle surface. This rapid and robust approach provides synthetic pathway to tunable composition, demonstrated by tuning surface charge and content of spin labels on nanodiamond. The supported phospholipid bilayer interface increases the detection sensitivity about one-order-of-magnitude. Also, a theoretical model of the system is provided, which shows excellent agreement with experimental results. Merging biocompatibility, modularity, and outstanding spin sensitivity in one nanomaterial provides a foundation for development of multifunctional nanoparticles suitable for highly sensitive monitoring of local magnetic field fluctuations and paramagnetic species under physiological conditions. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2019
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