The emerging connections between IGF1, the intestinal microbiome, Lactobacillus strains and bone growth

0492016 - MBÚ 2019 RIV GB eng J - Journal Article
Poinsot, P. - Schwarzer, Martin - Peretti, N. - Leulier, F.
The emerging connections between IGF1, the intestinal microbiome, Lactobacillus strains and bone growth.
Journal of Molecular Endocrinology. Roč. 61, č. 1 (2018), s. 103-113. ISSN 0952-5041. E-ISSN 1479-6813
R&D Projects: GA ČR(CZ) GJ18-07015Y
Grant - others:Nadační fond na podporu vědy(CZ) Neuron
Institutional support: RVO:61388971
Keywords : IGF * growth factors * bone
OECD category: Physiology (including cytology)
Impact factor: 3.744, year: 2018

In most animal species, postnatal growth is controlled by conserved insulin/insulinlike growth factor (IGF) signaling. In mammals, juvenile growth is characterized by a longitudinal bone growth resulting from the ossification of the growth plate. This ossification is under IGF1 influence through endocrine and paracrine mechanisms. Moreover, the nutritional status has been largely described as an important factor influencing the insulin/insulin-like growth factor signaling. It is now well established that the gut microbiota modulates the nutrient availability of its host. Hence, studies of the interaction between nutritional status, gut microbiota and bone growth have recently emerged. Here, we review recent findings using experimental models about the impact of gut bacteria on the somatotropic axis and its consequence on the bone growth. We also discuss the perspectives of these studies in opening an entire field for clinical interventions.
Permanent Link: http://hdl.handle.net/11104/0285606