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Study of the production yields of .sup.18./sup.F, .sup.11./sup.C, .sup.13./sup.N and .sup.15./sup.O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals
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SYSNO ASEP 0488129 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Study of the production yields of 18F, 11C, 13N and 15O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals Author(s) Amato, E. (IT)
Italiano, A. (IT)
Margarone, Daniele (FZU-D) RID, ORCID
Pagano, B. (IT)
Baldari, S. (IT)
Korn, Georg (FZU-D) RID, ORCIDNumber of authors 6 Source Title Nuclear Instruments & Methods in Physics Research Section A. - : Elsevier - ISSN 0168-9002
Roč. 811, Mar (2016), s. 1-5Number of pages 5 s. Language eng - English Country NL - Netherlands Keywords plasma laser ; proton acceleration ; positron emission tomography ; microfluidics Subject RIV BL - Plasma and Gas Discharge Physics OECD category Fluids and plasma physics (including surface physics) R&D Projects ED1.1.00/02.0061 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF15_008/0000162 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FZU-D - RVO:68378271 UT WOS 000368635700001 EID SCOPUS 84951783165 DOI 10.1016/j.nima.2015.12.011 Annotation The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of microfluidics labeling approaches. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources such that expected at the ELI-Beamlines facility. F-18, C-11, N-13 and O-15 production yields were calculated through the TALYS software, by taking into account the broad proton spectra expected. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of F-18-, C-11- and N-13-labeled radio pharmaceuticals exploiting fast and efficient microfluidic labeling systems. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2018
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