0485164 - ÚŽFG 2018 CZ eng K - Conference Paper (Czech conference)
Vochozková, Petra - Klymiuk, N. - Wolf, E. - Ellederová, Zdeňka - Motlík, Jan
Evaluation of strategies for humanization of the entire porcine HTT locus.
The 4th Animal Models of Neurodegenerative Diseases. Liběchov: ÚŽFG AV ČR, v. v. i., 2017, s. 25-26.
[Animal Models of Neurodegenerative Diseases /4./. Liblice (CZ), 22.10.2017-24.10.2017]
R&D Projects: GA MŠMT(CZ) LO1609; GA MŠMT 7F14308
Institutional support: RVO:67985904
Keywords : minipig model * HTT locus
OECD category: Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

Because fully suitable large animal models are still lacking for Huntington´s disease, we would like to generate a new minipig model which will have an entirely humanized HTT locus. Given the large size of the HTT gene (approx. 160 kb) we will test two different approaches to humanize the porcine HTT locus in porcine kidney cells (PKCs).
Permanent Link: http://hdl.handle.net/11104/0280237