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Ganoderma lucidum extract modifies the effects of 5-fluorouracil in colorectal cancer cell lines.
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SYSNO ASEP 0477070 Document Type C - Proceedings Paper (int. conf.) R&D Document Type O - Ostatní Title Ganoderma lucidum extract modifies the effects of 5-fluorouracil in colorectal cancer cell lines. Author(s) Čumová, Andrea (UEM-P)
Opattová, Alena (UEM-P)
Vodenková, Soňa (UEM-P) ORCID, RID
Horák, Josef (UEM-P) ORCID
Slíva, D. (US)
Vodička, Pavel (UEM-P) RIDSource Title Cellular signalling and cancer therapy. - Cavtat : EMBO Conference, 2016 Pages s. 92-92 Number of pages 1 s. Action Cellular signalling and cancer therapy Event date 27.05.2016 - 31.05.2016 VEvent location Cavtat Country HR - Croatia Language eng - English Country HR - Croatia Keywords colorectal cancer ; natural compound ; DNA damage ; 5-fluorouracil ; colorectal cell lines ; survival Subject RIV EB - Genetics ; Molecular Biology R&D Projects LH13061 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NV15-27580A GA MZd - Ministry of Health (MZ) Institutional support UEM-P - RVO:68378041 Annotation Colorectal cancer is the second most common type of cancer and the second common cause of cancer related death in Europe. 5-Fluorouracil (5-FU) is widely used in treatment of various cancers including CRC, but apart from the cytotoxic effect on cancer cells may also cause adverse toxic side effects. Ganoderma Lucidum (GLC) is a mushroom used in Traditional Eastern Medicine which exhibits anti-cancer and anti-proliferative effects in vitro. The aim of this study is to define interaction between 5FU and GL extracts and their simultaneous effect on survival and DNA damage in several CRC cell lines. The most prominent results is significant decrease survival in CRC lines after combined 5FU and GL treatment and significant increase of damage in HCT116 by 41,6%(0,003)after combined treatment. These facts may have an impact to cancer research and therapy. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2017
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