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Post-transcriptional mending of gene sequences: looking under the hood of mitochondrial gene expression in diplonemids

  1. 1.
    SYSNO ASEP0468794
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitlePost-transcriptional mending of gene sequences: looking under the hood of mitochondrial gene expression in diplonemids
    Author(s) Valach, M. (CA)
    Moreira, S. (CA)
    Faktorová, Drahomíra (BC-A) RID, ORCID
    Lukeš, Julius (BC-A) RID, ORCID
    Burger, G. (CA)
    Source TitleRNA biology. - : Taylor & Francis - ISSN 1547-6286
    Roč. 13, č. 12 (2016), s. 1204-1211
    Number of pages8 s.
    Publication formPrint - P
    Languageeng - English
    CountryUS - United States
    KeywordsCryptic genes ; gene fragmentation ; trans-splicing ; RNA editing ; multipartite mtDNA ; diplonemids
    Subject RIVEB - Genetics ; Molecular Biology
    R&D ProjectsGA15-21974S GA ČR - Czech Science Foundation (CSF)
    Institutional supportBC-A - RVO:60077344
    UT WOS000390670300005
    EID SCOPUS85003794187
    DOI10.1080/15476286.2016.1240143
    AnnotationThe instructions to make proteins and structural RNAs are laid down in gene sequences. Yet, in certain instances, these primary instructions need to be modified considerably during gene expression, most often at the transcript level. Here we review a case of massive post-transcriptional revisions via trans-splicing and RNA editing, a phenomenon occurring in mitochondria of a recently recognized protist group, the diplonemids. As of now, the various post-transcriptional steps have been cataloged in detail, but how these processes function is still unknown. Since genetic manipulation techniques such as gene replacement and RNA interference have not yet been established for these organisms, alternative strategies have to be deployed. Here, we discuss the experimental and bioinformatics approaches that promise to unravel the molecular machineries of trans-splicing and RNA editing in Diplonema mitochondria.
    WorkplaceBiology Centre (since 2006)
    ContactDana Hypšová, eje@eje.cz, Tel.: 387 775 214
    Year of Publishing2017
Number of the records: 1  

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