Nanocarbon allotropes — graphene and nanocrystalline diamond — promote cell proliferation

0464157 - FZÚ 2017 RIV DE eng J - Journal Article
Verdanová, M. - Rezek, Bohuslav - Brož, A. - Ukraintsev, Egor - Babchenko, Oleg - Artemenko, Anna - Ižák, Tibor - Kromka, Alexander - Kalbáč, Martin - Hubálek Kalbáčová, M.
Nanocarbon allotropes — graphene and nanocrystalline diamond — promote cell proliferation.
Small. Roč. 12, č. 18 (2016), s. 2499-2509. ISSN 1613-6810. E-ISSN 1613-6829
R&D Projects: GA ČR(CZ) GBP108/12/G108; GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GBP108/12/G108
Institutional support: RVO:68378271 ; RVO:61388955
Keywords : graphene * diamond * cell * cell proliferation
Subject RIV: BO - Biophysics; CF - Physical ; Theoretical Chemistry (UFCH-W)
Impact factor: 8.643, year: 2016

Two profoundly different carbon allotropes – nanocrystalline diamond and graphene – are of considerable interest from the viewpoint of a wide range of biomedical applications including implant coating, drug and gene delivery, cancer therapy, and biosensing. Osteoblast adhesion and proliferation on nanocrystalline diamond and graphene are compared under various conditions such as differences in wettability, topography, and the presence or absence of protein interlayers between cells and the substrate. The materials are characterized in detail by means of scanning electron microscopy, atomic force microscopy, photoelectron spectroscopy, Raman spectroscopy, and contact angle measurements. In vitro experiments have revealed a significantly higher degree of cell proliferation on graphene than on nanocrystalline diamond and a tissue culture polystyrene control material. Proliferation is promoted, in particular, by hydrophobic graphene with a large number of nanoscale wrinkles.

Permanent Link: http://hdl.handle.net/11104/0263173