Number of the records: 1
Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets
- 1.
SYSNO ASEP 0463316 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets Author(s) Sojka, Daniel (BC-A) RID, ORCID
Hartmann, David (BC-A) ORCID, RID
Bartošová-Sojková, Pavla (BC-A) RID, ORCID
Dvořák, Jan (UMG-J) RIDSource Title Trends in Parasitology. - : Elsevier - ISSN 1471-4922
Roč. 32, č. 9 (2016), s. 708-723Number of pages 16 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords aspartic peptidases ; cathepsin D ; hemoglobinolysis ; parasites ; vectors Subject RIV GJ - Animal Vermins ; Diseases, Veterinary Medicine R&D Projects GA14-33693S GA ČR - Czech Science Foundation (CSF) GA13-11043S GA ČR - Czech Science Foundation (CSF) GAP302/11/1481 GA ČR - Czech Science Foundation (CSF) Institutional support BC-A - RVO:60077344 ; UMG-J - RVO:68378050 UT WOS 000383302000008 EID SCOPUS 84991672014 DOI 10.1016/j.pt.2016.05.015 Annotation Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antiparasite intervention strategy. APDs have been considered as virulence factors of Trypanosoma cruzi and Leishmania spp., and have been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites. APDs also initiate blood digestion as components of multienzyme proteolytic complexes in malaria, platyhelminths, nematodes, and ticks. Increasing DNA and RNA sequencing data indicate that parasites express multiple APD isoenzymes of various functions that can now be specifically evaluated using new functional-genomic and biochemical tools, from which we can further assess the potential of APDs as targets for novel effective intervention strategies against parasitic diseases that still pose an alarming threat to mankind. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2017
Number of the records: 1