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Assessing host-virus codivergence for close relatives of Merkel cell polyomavirus infecting African great apes
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SYSNO ASEP 0462538 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Assessing host-virus codivergence for close relatives of Merkel cell polyomavirus infecting African great apes Author(s) Madinda, N. F. (DE)
Ehlers, B. (DE)
Wertheim, J. O. (US)
Akoua-Koffi, C. (CI)
Bergl, R. A. (US)
Boesch, C. (DE)
Akonkwa, D. B. M. (CG)
Eckardt, W. (US)
Fruth, B. (DE)
Gillespie, T. R. (US)
Gray, M. (RW)
Hohmann, G. (DE)
Karhemere, S. (CG)
Kujirakwinja, D. (CG)
Langergraber, K. (DE)
Muyembe, J.-J. (CG)
Nishuli, R. (CD)
Pauly, M. (DE)
Petrželková, Klára Judita (UBO-W) RID, SAI, ORCID
Robbins, M. M. (DE)
Todd, A. (CF)
Schubert, G. (DE)
Stoinski, T. S. (US)
Wittig, R. M. (DE)
Zuberbühler, K. (CH)
Peeters, M. (FR)
Leendertz, F. H. (DE)
Calvignac-Spencer, S. (DE)Number of authors 28 Source Title Journal of Virology - ISSN 0022-538X
Roč. 90, č. 19 (2016), s. 8531-8541Number of pages 11 s. Language eng - English Country US - United States Keywords JC virus ; divergence times ; evolution ; phylogenies ; selection ; bats ; coevolution ; population ; chimpanzee ; diversity Subject RIV GJ - Animal Vermins ; Diseases, Veterinary Medicine R&D Projects GA206/09/0927 GA ČR - Czech Science Foundation (CSF) Institutional support UBO-W - RVO:68081766 UT WOS 000383761900014 EID SCOPUS 84990198224 DOI 10.1128/JVI.00247-16 Annotation It has long been hypothesized that polyomaviruses (PyV; family Polyomaviridae) codiverged with their animal hosts. In contrast, recent analyses suggested that codivergence may only marginally influence the evolution of PyV. We reassess this question by focusing on a single lineage of PyV infecting hominine hosts, the Merkel cell polyomavirus (MCPyV) lineage. By characterizing the genetic diversity of these viruses in seven African great ape taxa, we show that they exhibit very strong host specificity. Reconciliation analyses identify more codivergence than noncodivergence events. In addition, we find that a number of host and PyV divergence events are synchronous. Collectively, our results support codivergence as the dominant process at play during the evolution of the MCPyV lineage. More generally, our results add to the growing body of evidence suggesting an ancient and stable association of PyV and their animal hosts. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2017
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