Is nucleus subthalamicus involved in thinking? Separation of conscious and subconscious cognition component in the subthalamic nucleus using P300 and MMN protocols

0456445 - ÚPT 2016 IE eng A - Abstract
Minks, E. - Jurák, Pavel - Chládek, Jan - Hummelová, Z. - Halámek, Josef - Minksová, A. - Bareš, M.
Is nucleus subthalamicus involved in thinking? Separation of conscious and subconscious cognition component in the subthalamic nucleus using P300 and MMN protocols.
Clinical Neurophysiology. Elsevier. Roč. 126, č. 3 (2015), e49-e50. ISSN 1388-2457. E-ISSN 1872-8952.
[Congress of the Czech and Slovak Society of Clinical Neurophysiology /61./. 15.10.2015-18.10.2015, Olomouc]
Institutional support: RVO:68081731
Keywords : oddball * MMN * P300 * ERP * EEG * DBS * STN * conscious cognitive processes
Subject RIV: BH - Optics, Masers, Lasers

P300 wave is considered a correlate of cognitive process and an oddball paradigm is used for its recording. MMN (Mismatch negativity) is considered a correlation of automatic sensory memory on a subconscious level and also a reflection of subconscious primitive sensory intelligence. When the MMN is recorded the same protocol as P300 paradigm is used, only with the difference that the proband pays no attention to the stimuli. The aim of this study was to compare evoked potentials from the P300 paradigm against MMN paradigm, both recorded in the subthalamic nucleus (STN) and thus electrophysiologically isolate conscious cognition component in this structure. We included 3 patients with Parkinson´s disease and recorded the evoked potentials using protocols P300 and MMN during installation of DBS (Deep brain stimulation). The difference between evoked potentials of MMN and P300 protocols in latency of 200-400 ms suggests that STN is involved in conscious cognitive processes at the time of stimuli application. Thus the thinking at a given time is not a function of the brain cortex only. What component of the cognitive processes STN does represent cannot be exactly specified. Although oddball paradigm is very simple, during this paradigm the patient uses a variety of cognitive functions attention, executive function, working memory, calculation and proper level of motivation is necessary too.
Permanent Link: http://hdl.handle.net/11104/0256979