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Markers of Oxidative Stress and Inflammation Are More Elevated in the Exhaled Breath Condensate of Workers Exposed to nano-TiO2 than to nano-Fe Oxide Particles
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SYSNO ASEP 0449589 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Markers of Oxidative Stress and Inflammation Are More Elevated in the Exhaled Breath Condensate of Workers Exposed to nano-TiO2 than to nano-Fe Oxide Particles Author(s) Pelclová, D. (CZ)
Zacharov, S. (CZ)
Ždímal, Vladimír (UCHP-M) RID, ORCID, SAI
Fenclová, Z. (CZ)
Vlčková, Š. (CZ)
Syslová, K. (CZ)
Kuzma, Marek (MBU-M) ORCID, RID
Navrátil, Tomáš (UFCH-W) RID, ORCID
Komarc, M. (CZ)
Kačer, P. (CZ)ISSN 1556-3650 Source Title Clinical Toxicology, Volume 53, Issue 4. - New York : INFORMA HEALTHCARE, 2015 - ISSN 1556-3650 Pages 297-298, s. 297-298 Number of pages 2 s. Publication form Online - E Action International Congress of the European Association of Poisons Centres and Clinical Toxicologists /35./ Event date 26.09.2015-29.09.2015 VEvent location Malta Country MT - Malta Event type EUR Language eng - English Country US - United States Keywords occupational ; biomonitoring ; nanoparticles Subject RIV CF - Physical ; Theoretical Chemistry Institutional support UCHP-M - RVO:67985858 ; UFCH-W - RVO:61388955 ; MBU-M - RVO:61388971 UT WOS 000351927300143 DOI 10.3109/15563650.2015.1024953 Annotation This study suggests adverse effects of exposure to aerosols containing a high proportion of nanoparticles of TiO 2 and Fe oxides with signs of inflammation and genotoxic/carcinogenic effect due to the oxidation of nucleic acids. As TiO2 and Fe oxides are of low toxicity, the effects may be attributed to the nanopar- ticles. The diameter of inhaled particles seems more important than the chemical composition, because nano-sized particles are able to cross cell membranes, unlike chemically identically bulk TiO2 and Fe oxides. As the non-soluble particles are removed from the lungs with a very long half-life, EBC appears a preferred biological fluid for the evaluation of their deleterious effect. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2016 Electronic address http://www.tandfonline.com/doi/pdf/10.3109/15563650.2015.1024953
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