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Chiroptical spectroscopy as a sensitive tool for the conformational analysis of antimicrobial peptides
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SYSNO ASEP 0449041 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Chiroptical spectroscopy as a sensitive tool for the conformational analysis of antimicrobial peptides Author(s) Kocourková, L. (CZ)
Novotná, P. (CZ)
Čujová, Sabína (UOCHB-X) RID
Čeřovský, Václav (UOCHB-X) RID, ORCID
Urbanová, M. (CZ)
Setnička, V. (CZ)Source Title Proceedings of the 11th International Students Conference "Modern Analytical Chemistry". - Prague : Charles University in Prague, Faculty of Science, 2015 / Nesměrák K. - ISBN 978-80-7444-036-6 Pages s. 67-73 Number of pages 7 s. Publication form Print - P Action International Students Conference "Modern Analytical Chemistry" /11./ Event date 22.09.2015-23.09.2015 VEvent location Prague Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords antimicrobial peptides ; circular dichroism ; conformation ; liposomes ; model membranes Subject RIV CB - Analytical Chemistry, Separation R&D Projects GAP208/11/0105 GA ČR - Czech Science Foundation (CSF) Institutional support UOCHB-X - RVO:61388963 UT WOS 000383853900012 Annotation We tested the utilization of electronic and vibrational circular dichroism for the conformational study of antimicrobial peptides on two examples: melectin and antapin in different solutions of liposomes and micelles mimicking bacterial or eukaryotic membranes. The results show significant content of the alpha-helical conformation in an environment mimicking the bacterial membrane, while it was considerably low in the eukaryotic membrane-mimicking environment. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2017
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