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Novel thermo-responsive double-hydrophilic and hydrophobic MPEO-b-PEtOx-b-PCL triblock terpolymers: synthesis, characterization and self-assembly studies
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SYSNO ASEP 0440990 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Novel thermo-responsive double-hydrophilic and hydrophobic MPEO-b-PEtOx-b-PCL triblock terpolymers: synthesis, characterization and self-assembly studies Author(s) Petrova, Svetlana (UMCH-V) RID, ORCID
Venturini, Cristina Garcia (UMCH-V)
Jäger, Alessandro (UMCH-V) RID, ORCID
Jäger, Eliezer (UMCH-V) ORCID, RID
Černoch, Peter (UMCH-V) RID, ORCID
Kereiche, S. (CZ)
Kováčik, L. (CZ)
Raška, I. (CZ)
Štěpánek, Petr (UMCH-V) RID, ORCIDSource Title Polymer. - : Elsevier - ISSN 0032-3861
Roč. 59, 24 February (2015), s. 215-225Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords MPEO-b-PEtOx-b-PCL triblock terpolymers ; light-scattering ; thermo-responsive nanoparticles Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GAP208/10/1600 GA ČR - Czech Science Foundation (CSF) 7F14009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 UT WOS 000350618000025 EID SCOPUS 84921689145 DOI 10.1016/j.polymer.2015.01.009 Annotation A series of new double-hydrophilic and hydrophobic biocompatible ABC triblock terpolymers with different molecular weights of the PCL block (herein referred to as MPEO44-b-PEtOx263-b-PCL87, MPEO44-b-PEtOx263-b-PCL175, MPEO44-b-PEtOx263-b-PCL262) were successfully synthesized by a three-step pathway using a combination of living cationic and anionic ring-opening polymerization (ROP). First, α-methoxy-ω-hydroxy-poly(ethylene oxide) (MPEO) was end-capped with p-toluenesulfonyl chloride. ω-Tosyl-MPEO was used in the second step as a macroinitiator for the ROP of 2-ethyl-2-oxazoline (EtOx) to form the diblock copolymer, MPEO-b-PEtOx. Finally, the prepared diblock copolymer was used as a macroinitiator for the design of the PCL block by ROP of ε-caprolactone (ε-CL). Properties of the newly obtained compounds (macroinitiator, AB diblock and ABC triblock terpolymers) were assessed by 1H NMR and FT-IR spectroscopy and SEC analysis. The selected MPEO44-b-PEtOx263-b-PCL87 triblock terpolymers self-assembled under buffer-simulated physiological conditions into nanoparticles, which were fully characterized by static and dynamic light scattering, nanoparticle tracking analysis and cryo-transmission electron microscopy (cryo-TEM). The combination of the scattering methods revealed a temperature-induced aggregation driven by hydrogen bonding with the LCST approximately between 56 and 60 °C. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2015
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